What’s the study about?

The Disparities and Cancer Epidemiology-Colorectal Cancer (DANCE-CRC) study is establishing a diverse cohort of Black and White colorectal cancer (CRC) patients living in Louisiana and metropolitan Detroit. The purpose of the DANCE-CRC study is to better understand why some people develop more aggressive types of CRC. We will look at social, genetic, geographic, lifestyle, and molecular factors. Including people from different social and genetic backgrounds in this study helps ensure that advances in knowledge benefit everyone.

Despite overall declines in CRC rates, Black individuals still experience higher incidence and mortality compared to White individuals. This disparity may be partly due to more aggressive tumor types and specific genetic mutations that are more common among Black CRC survivors. Moreover, factors like chronic inflammation, which is likely influenced by socioeconomic factors and structural racism, could be playing a role in these racial differences. The DANCE project aims to further understand these disparities by studying both genetic and social factors that might affect CRC development in this new cohort of Black and White CRC survivors.